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KMID : 0369820000300040295
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Jorunal of Korean Pharmaceutical Sciences
2000 Volume.30 No. 4 p.295 ~ p.297
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Determination of Erosion Rate of the Biodegradable Polymer
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박은석/Park ES
지상철/Chi SC
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Abstract
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A new method to evaluate erosion of biodegradable polymer, polyanhydrides, was developed. The polymer devices were prepared with the melt-casting method and weight loss was accurately measured after agitating the devices in buffers (pH 1-9), and removing the device at selected time intervals and freeze-drying the device. The erosion rate was estimated from the plot of the weight loss(%) of device as a function of time. The freeze-drying technique used in this study is particularly useful for estimating the erosion rate of biodegradable polymer.
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KEYWORD
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Erosion, Biodegradable polymer, Polyanhydrides, Freeze-drying
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